Vitamin K2 (MK-4)-13C6 is a stable isotope-labeled form of menaquinone-4 used as an internal standard for quantitative analysis of vitamin K2 in biological and clinical samples. This certified reference material (CRM) solution is prepared at a concentration of 10 µg/mL in acetonitrile and supplied in a flame-sealed 1 mL ampule to maintain stability and minimize contamination.

The material is fully characterized as a certified reference material and is accompanied by a Certificate of Analysis (CoA) documenting concentration accuracy, uncertainty, stability, and traceability. The isotopically labeled compound is chemically identical to native vitamin K2 (MK-4) except for the incorporation of carbon-13 atoms, enabling accurate quantification by mass spectrometry.

This single-component CRM is suitable for use as an internal standard, calibration standard, or quality control material for chromatographic and mass spectrometric determination of vitamin K2. It is compatible with gas chromatography (GC) and liquid chromatography (LC) techniques, particularly LC-MS/MS methods commonly used in clinical testing and research.

Typical applications include assessment of vitamin K2 deficiency, investigation of vitamin K-dependent proteins involved in coagulation and bone metabolism, and quantitative analysis of MK-4 in serum, plasma, and other biological matrices.

This certified reference material is supplied with a certificate of analysis providing traceable concentration values suitable for calibration, method validation, and analytical quality control.

Shipping and Storage Notice
Please note that shipping and long-term storage conditions for certified reference materials may differ. Manufacturers determine the most appropriate shipping method based on product stability and shipping data. Some CRM standards may ship at ambient temperature even though recommended long-term storage conditions are refrigerated or frozen. This does not affect product integrity when handled according to manufacturer documentation.